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Mad Cowboy looks at Mad Cow Disease and the politics of agriculture, ecological sustainability, and human health, while making a strong statement about industrial farming and its impact on the planet and on our fellow beings. The film's main focus is Howard Lyman, a 4th generation former cattle rancher from Montana who became famous by his appearance on the Oprah Winfrey Show in 1996 and the subsequent legal battle with the Cattleman's Association.