Kingsbury Run drains the central portion of Cleveland east of the Cuyahoga River and a portion of the west end of Shaker Heights. It has a total drainage area of 7.8 square miles of total length of 4.3 miles. Kingsbury Run flows predominantly east-to-west with two branches that merge east of E. 37th street, south of Woodland Ave.

The main stem begins at E. 47th street, south of Woodland Ave. and eventually enters the Cuyahoga River at approximately River Mile 4, just north of the old Jefferson Ave. bridge.

Kingsbury Run has the following open sections: a 1,000-foot section from the confluence with the Cuyahoga River to the mouth of the culvert; a 1,100-foot section between E. 78th street and Grand Ave., 250 feet north of Colfax road; and a 900-foot section between E. 84th street and E. 87th street, north of Kinsman road.

The remaining portion of Kingsbury Run is entirely underground and is a combination of culverted stream sections and storm sewers, serving as an overflow-receiving sewer for combined sewers during high flow conditions.